Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
| Author | |
|---|---|
| Abstract |
:
DNA-PK and PARP inhibitors sensitize cancer cells to chemo- and radiotherapy. ETS transcription factors (EWS-FLI1) have been described as biomarkers for PARP-inhibitor sensitivity. Sensitivity to single agent PARP inhibitors has so far been limited to homologous recombination repair (HRR) deficient tumors, exploiting synthetic lethality. |
| Year of Publication |
:
2017
|
| Journal |
:
Oncotarget
|
| Volume |
:
8
|
| Issue |
:
69
|
| Number of Pages |
:
113418-113430
|
| Date Published |
:
2017
|
| DOI |
:
10.18632/oncotarget.21300
|
| Short Title |
:
Oncotarget
|
| Download citation |
