Fluorescence immunophenotyping and interphase cytogenetics (FICTION) detects BCL6 abnormalities, including gene amplification, in most cases of nodular lymphocyte-predominant Hodgkin lymphoma.
| Author | |
|---|---|
| Abstract |
:
BCL6 translocations are a frequent finding in B-cell lymphomas of diverse subtypes, including some cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). However, reliable analysis of BCL6 rearrangements using fluorescence in situ hybridization is difficult in NLPHL because of the relative paucity of neoplastic cells. Combined immunofluorescence microscopy and fluorescence in situ hybridization, or fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms (FICTION), permits targeted analysis of neoplastic cells. |
| Year of Publication |
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2014
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| Journal |
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Archives of pathology & laboratory medicine
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| Volume |
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138
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| Issue |
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4
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| Number of Pages |
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538-42
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| ISSN Number |
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0003-9985
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| URL |
:
https://meridian.allenpress.com/aplm/article-lookup/doi/10.5858/arpa.2012-0663-OA
|
| DOI |
:
10.5858/arpa.2012-0663-OA
|
| Short Title |
:
Arch Pathol Lab Med
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| Download citation |
