Temperature sensitivity of two-pore (K2P) potassium channels.
| Author | |
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| Abstract |
:
At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK. |
| Year of Publication |
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0
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| Journal |
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Current topics in membranes
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| Volume |
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74
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| Number of Pages |
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113-33
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| Date Published |
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2014
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| ISSN Number |
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1063-5823
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| URL |
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https://linkinghub.elsevier.com/retrieve/pii/B978-0-12-800181-3.00005-1
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| DOI |
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10.1016/B978-0-12-800181-3.00005-1
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| Short Title |
:
Curr Top Membr
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| Download citation |
